Causes for hypoperfusion include low blood pressure, heart failure or loss of blood volume. Ischemia can affect any organ of the body. Intermittent ischemia of the heart muscle (cardiac ischemia) is called angina. Intermittent ischemia of the brain is called a Transient Ischemic Attack (TIA) or "mini stroke".

the reduced blood flow was mostly in the frontal and parietal zones.

 lower-sodium oxybate (LXB)

what causes cerebral hypoperfusion?

AD mice = Alzheimer's Disease in mice

BBB leakage = blood-brain barrier leakage

BBB controls brain supply with oxygen and nutrients, and protects the brain
from toxic metabolites. 

rCCA right common carotid artery 
mice are subjected to permanent ligation in the rCCA to induce
mild cerbral hypoperfusion.

mice are also subjected to induced myocardial infarction (MI)
in other studies

MCA = Middle Cerebral artery